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Tramatic Brain Injury (TBI)

Traumatic brain injury (TBI), including that induced by mild, repetitive, non-penetrating injuries (eg, sports-related concussion) represents an enormous public health problem that is inadequately understood, has uncertain predictors, and is not addressed by existing therapeutics. Improving this situation will require a better understanding of the circumstances and underlying mechanisms by which brain injuries, even when relatively minor, lead to progressive neurodegeneration.

Twenty-four applications were received.  Eight proposals have been funded to date.

Oligodendrocyte Injury and Repair Following Repetitive Mild Traumatic Brain Injury
Dwight E. Bergles, Visar Belegu, Ibolja Cernak, Andres Hurtado, Shin Kang, John McDonald, Susumu Mori, Mikhail Pletnikov, Martin Pomper, Peter van Zijl; Neuroscience, International Center for Spinal Cord Injury /Kennedy Krieger Institute, Applied Physics Laboratory, Radiology, Psychiatry, FM Kirby Center/Kennedy Krieger Institute

The Center for Quantitative Neuroscience: a core for population euroanalytics and translational systems neuroscience

Brian S Caffo, Ciprian M. Crainiceanu, John W. Krakauer, Martin A. Lindquist, James J. Pekar, Robert D. Stevens; Biostatistics/Public Health, Neurology, Kennedy Krieger Institute/Radiology, Anesthesiology & Critical Care Medicine

TBI Animal Model Core
Raymond C. Koehler, Vassilis E. Koliatsos, Courtney L. Robertson, Alena Savonenko; Anesthesiology & Critical Care Medicine, Psychiatry & Behavioral Sciences, Pathology

Long-term plasticity and recovery in pediatric TBI rat model
Galit Pelled, Courtney L. Robertson, Raymond Koehler; Radiology/Kennedy Krieger Institute, Anesthesiology & Critical Care Medicine 

Neuroimaging & plasma markers for predicting outcomes after mild traumatic brain injury
Vani Rao, Kathleen B. Kortte, Alena Horska, Susumu Mori, David Yousem, Norman Haughey, Allen Everett, Ed Bessman, Ding-Fen Han; Psychiatry, Physical Medicine & Rehabilitation, Radiology, Neurology, Pediatrics, Emergency Medicine

Development and characterization of a novel animal model of inflicted childhood neurotrauma in immature rats
Courtney L. Robertson, Sujatha Kannan, Vassilis E. Koliatsos, Thierry A.G.M. Huisman, Susumu Mori, Allen D. Everett, Melania M. Bembea; Anesthesiology & Critical Care Medicine , Pathology, Radiology, Pediatrics

“Wake up and walk out”: predicting and tracking recovery from traumatic brain injury
Robert D Stevens, John W. Krakauer, Steven Yantis, Vanessa Raymont; Anesthesiology & Critical Care Medicine , Neurology, Psychological & Brain Sciences, Psychiatry & Behavioral Sciences

Biomarkers of mild traumatic brain injury in children: predicting outcome and understanding recovery
Stacy Suskauer, Allen D. Everett, Jun Hau, C. Jean Ogborn, James J. Pekar, Jennifer Reesman, Aylin Tekes, Hilary J. Vernon; Kennedy Krieger Institute/Rehabilitation, Pediatrics, Radiology/Kennedy Krieger Institute, Psychiatry/Kennedy Krieger Institute


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