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Research in this area addresses the processes underlying this devastating disease. Recent advances in molecular techniques have allowed genetic approaches towards this complex disorder. Collaborative studies in the forefront of this field are trying to identify the genes involved in schizophrenia and how disruption of these normal biological processes leads to illness.
Research in Schizophrenia projects:
Twenty-six applications were received. Five awards have been given to date.
Microarray detection of retrotransposons and copy number variations in schizophrenia
Jef Boeke, David Valle, Ann Pulver; Departments of Molecular Biology and Genetics, and Psychiatry and Behavioral Sciences
Schizophrenia therapeutics: Adult stem cell model development
We are developing cell models related to psychiatric illness taking advantage of a genetic mutation in a gene called DISC1 which can cause schizophrenia and psychotic depression. We have previously generated a genetic mouse model which recapitulates aspects of abnormal behavior, and we are now developing cell models from the mice, so as to be able to study molecular and cellular processes, and possibly to screen for therapeutic interventions.
Christopher Ross, Hongjun Song; Departments of Psychiatry and Behavioral Sciences, and Neurology
Glucose metabolism and oxidative stress-associated cellular susceptibility in schizophrenia: a systematic study using patient tissues and cells
Akira Sawa, Sandra Lin, David Schretlen, Nicola Cascella, Peter Barker, Thomas Sedlak; Departments of Psychiatry and Behavioral Sciences, Otolaryngology, and Radiology
The role of NRG3 in schizophrenia
David Valle, Dimitri Avramopoulos, Ann Pulver, Andy McCallion, Michael Zwick, Akira Sawa, Hongjun Song; Departments of Genetic Medicine, Psychiatry and Behavioral Sciences, Comparative Medicine, and Neurology
BACE1-related NRG-ErbB4 signaling and schizophrenia
Philip Wong, Alena Savonenko, Paul Worley, Don Price; Departments of Pathology and Neuroscience