The BSi has proudly hosted a variety of seminars, symposiums and conferences that highlight the work of BSi investigators. These talks are now available for a wider audience as video-talks, by clicking the titles below. More information is also available by viewing the investigator's departmental website as well as their published papers by clicking on the links provided.
Click here to see upcoming events and lectures listed in the the News & Events section of our website
This talk examines the technologies of Computational Anatomy and high throughput informatics for viewing structural and functional imagery at 1mm scale. A high throughput pipeline is discussed for indexing brains into high dimensional feature vectors which represent the anatomical and functional information.
Examples are examined, including the cell-cell hypotheses being studied in Huntington's PREDICT disease projects, as well as Alzheimer's BIOCARD and ADNI projects. Several machine learning methods are examined for discriminating and predicting disease onset in cohorts associated with various forms of dementia as well as aphasia.
Michael I. Miller, Ph.D., ENGR, MS,
Hershcel and Ruth Seder Professor of Biomedical Engineering,
Director, Center for Imaging Science
Johns Hopkins University Whiting School of Engineering
View Dr. Miller's webpage.
As neurologists we are often given the opportunity to learn about brain function from the unfortunate maladies of our patients. This new information also provides clues for better diagnosis and treatment. Here we will use disorders of eye movements, and in particular saccades (the rapid eye movements we use to change our gaze). We discuss three examples, patients who make abnormally slow saccades, patients who make uncalled for saccades, and patients who experience dizziness and imbalance as they climb out of the MRI machine. In each case we were able to make a major advance forward in understanding how the brain works, and how we might better treat our patients.
Ramat S, Leigh RJ, Zee DS, Optican LM. What clinical disorders tell us about the neural control of saccadic eye movements. Brain, 130:10-35, 2007.
Shaikh, A.G., Miura, K., Optican, L.M., Ramat, S., Leigh, R.J., Zee,D.S., A new familial disease of saccadic oscillations and limb tremor provides clues to mechanisms of common tremor disorders.Brain, 130:3020-3031, 2007.
Roberts, DC, Marcelli, V, Gillen, JS, Carey, JP, DellaSantina, CC, Zee, DS, MRI magnetic field stimulates rotational sensors of the brain, Current Biology, 2011.
David S. Zee, M.D.
Professor, Departments of Neurology, Ophthalmology, Otolaryngology-head and neck surgery, and Neuroscience
View Dr. Zee's webpage.
HIV pathogenesis in large part is mediated by hyperactivation of both innate and adaptive arms of the immune system. These responses separate natural hosts of HIV infection, which do not manifest disease, from non-natural hosts such as humans, which do. We have developed an SIV/macaque model that closely recapitulates AIDS and neurological disease in HIV-infected individuals. We are using this model to design rational therapeutics that suppress the hyper-responsiveness of the immune system yet do not further immunosuppress infected individuals.
M. Christine Zink, D.V.M., Ph.D., ACVP
Professor and Director, Department of Molecular and Comparative Pathobiology
Professor, Departments of Pathology & Molecular Microbiology and Immunology at Bloomberg School of Public Health
View Dr. Zink's webpage.
Why do people spend millions of dollars and years of work on monumental sculptures that have no practical function or utility? Because human visual experience is so rich that it has its own inherent value, which we call aesthetics. Great sculptors can evoke compelling visual experiences that justify the time and expense involved in their work. The power of such visual experiences must ultimately derive from visual representation systems of the brain. In this talk, Ed Connor discusses how the brain represents 3D shape and how shape representation might relate to aesthetic experience.
Yukako Yamane, Eric T Carlson, Katherine C Bowman, Zhihong Wang & Charles E Connor. A neural code for three-dimensional object shape in macaque inferotemporal cortex. Nature Neuroscience 11, 1352 - 1360 (2008)
Ed Connor, Ph.D.
Professor, Solomon H. Snyder Department of Neuroscience
Director, Zanvyl Krieger Mind/Brain Institute
View Dr. Conner's webpage.
I will argue that humans are truly the all-time twisted sex deviants of the mammalian world. Not because some of us get turned on by the sight of automobile exhaust systems, the smell of unwashed feet, or the idea of traffic cops in bondage. Rather, because the most prosaic and culturally sanctioned aspects of sexual activity in humans are far outside the mainstream of behavior for most of our closest animal relatives. How did it come to be this way? I contend that the most important determinant of human amorous and sexual behavior derive from quirky and suboptimal brain evolution. Within this evolutionary framework, I will discuss the brain's role in romantic love and mate choice, sexual arousal, orgasm and sexual orientation.
Linden, D.J. (2007) The Accidental Mind: How Brain Evolution Has Given Us Love, Memory, Dreams and God. Belknap Press of the Harvard University Press. Cambridge, MA. Translations: Spanish, Italian, German, Japanese, Korean and Chinese.
Linden, D.J. (2011) The Compass of Pleasure. Viking Press, New York, NY, USA and Oneworld Publications, Cambridge, United Kingdom. Translations: Dutch, German, Spanish, Chinese (Simplified Characters), Chinese (Complex Characters), Korean, Russian, Brazilian Portuguese, Japanese, Italian, Thai, French, Romanian.
David Linden, Ph.D.
Professor of Neuroscience
View Dr. Linden's webpage.
There is consistency in how healthy people move their eyes, arms, and legs. What is good about this way of moving, and why has our brain settled on this pattern? Here, I focus on the control of eye movements and suggest that the purpose of any movement is to acquire a more rewarding state. I suggest that the way the brain discounts reward in time explains why we move the way that we do. This framework has the potential to explain why disorders that affect processing of reward in the brain, like Parkinson's disease, depression, and Schizophrenia, result in changes in control of eye movements.
Reza Shadmehr, Ph.D.
Professor, Departments of Biomedical Engineering and Neuroscience
View Dr. Shadmehr's webpage.
Multitasking is ubiquitous in the modern world – we are faced with juggling the flow of information from a plethora of multimedia devices (computers, phones, TV, radio) competing for our attention. Among the most common, and potentially dangerous, cases of multitasking is talking on a mobile phone while driving. In this talk, Steven Yantis describes evidence that two tasks really can’t be carried out as rapidly as each alone – and switching between tasks comes with an almost completely unavoidable cost in time or accuracy. He explains how the architecture of the brain contains a structural bottleneck that leads to a delay in decision making when two incompatible tasks are carried out at the same time. Functional brain imaging experiments show how the brain responds during tasks requiring shifts of attention between vision and hearing, and how the brain controls the flow of information from the world that is used to guide action.
Steven Yantis, Ph.D.
Professor and Chair, Department of Psychological and Brain Sciences
View Dr. Yantis's webpage.
"In biology, it is often useful to define the quanititative rules governing a process, even if the underlying mechanisms are unknown"
Jeremy Nathans, M.D., Ph.D.
Professor, Departments of Molecular Biology and Genetics, Neuroscience, and Ophthalmology
View Dr. Nathans's webpage
"Are there therapeutic approaches that will augment HAART for treating HIV infection in CNS?"
Janice E. Clements, Ph.D.
Vice Dean for Faculty and Executive Director, BSi
Mary Wallace Stanton Professor of Faculty Affairs
University Distinguished Professor, Department of Molecular and Comparative Patholobiology
Professor, Departments of Neurology and Pathology
View Dr. Clements's webpage.
Huntington's Disease (HD) was presumably 'solved' when the culprit gene, encoding for the protein huntington was cloned in 1993. However, this discovery only heightened the disease's mystery, as HD is characterized by a massive, sometimes 90% shrinkage of the corpus striatum with far less damage to other brain regions and no systemic symptoms even though huntingtin is expressed uniformly throughout the brain and the rest of the body. We discovered that a striatal-selective protein Rhes binds avidly to mutant huntingtin and causes its transformation to a soluble, toxic form. Therapeutic possibilities emerge, as drugs blocking the binding of Rhes to mutant huntingtin might prevent/slow disease onset.
Solomon H. Snyder, M.D., D.Sc., D.Phil. (Hon. Causa)
Distinguished Service Professor, Departments of Neuroscience, Pharmacology and Psychiatry
View Dr. Snyder's webpage