drug discovery:

Spring 2016
“Introduction to Drug Discovery Research" 
Course #: ME:200.704
Course Director: Takashi Tsukamoto (ttsukamoto@jhmi.edu)
Location: Rangos Building Room 590
Time: 10:00 AM – 11:30 AM
Dates: Every Friday 1/8/2016-4/29/2016

This course deals with various aspects of the drug discovery process including target identification, medicinal chemistry, in vitro and in vivo drug screening methods, pharmacokinetics, drug safety, and intellectual property management. While the main focus of the course is centered on small molecule-based drugs, one lecture covers the principles of biologics-based drugs given the increasing interests in this area. The last two lectures are devoted to case studies in which discovery of particular drugs will be discussed in detail to provide further insights into the process of drug discovery research. Each lecture is given by an expert on that respective subject with many years of drug discovery research experience. Students will build a broad knowledge base that will allow them to prepare for a career in pharmaceutical research or basic medical science with implications for novel therapies.

Grades will be determined by quiz participation (given at the end of each lecture, 1/3), Mid-term Exam (1/3), and Final Exam (1/3). No quiz will be given at the first lecture.
Prerequisite: No prior knowledge in drug discovery is required. This course is recommended for students in the 2nd or subsequent years of their graduate program. Please contact Dr. Takashi Tsukamoto (ttsukamoto@jhmi.edu) for more information.

Topic                                                                                      Lecturer

1/08     Introduction                                                               Takashi Tsukamoto
1/15     Drug-like properties and druggable targets        Takashi Tsukamoto
1/22     in vitro Pharmacology I                                           Camilo Rojas
1/29     in vitro Pharmacology II                                          Camilo Rojas
2/05     in vitro Pharmacokinetics                                       Takashi Tsukamoto
2/12     in vivo Pharmacokinetics                                        Takashi Tsukamoto
2/19     Drug Safety                                                               Adaline Smith
2/26     Midterm Exam
3/04     Winter weather make-up day  (no lecture if the course is on schedule)
3/11     Spring Break
3/18     in vivo Pharmacology                                             Krystyna Wozniak
3/25     Intellectual Property                                               Jeff Childers
4/01     Lead Optimization                                                  Takashi Tsukamoto
4/08     Biologics                                                                  Tomas Mustelin
4/15     Case Study I (Sitagliptin)                                       Jim Barrow
4/22     Case Study II (Imatinib)                                         David Meyers
4/29     Final Exam

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