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Treating the Debilitating Depression Precipitated by MS
Adam Kaplin, M.D., Ph.D.
Assistant Professor, Department of Psychiatry & Behavioral Sciences

Dr. Adam KaplinMS causes clinical depression in affected patients through the effects of active CNS inflammation on the brain. Thus, Depression is not to be seen as weakness or a character flaw, but rather just another comorbidity of this disease. Depression is the most treatable comorbidity of MS, with patients achieving complete remission of their clinical depression with proper treatment.

The devastating impact depression has on patients with MS is seen throughout MS research. Depression is the number one correlate of quality of life for patients and their caregivers with MS. Suicide from depression is the 3rd leading cause of death in MS across the lifespan. 30% of patients with MS have suicidal ideation, and 10% of patients with MS will attempt suicide at some point during the course of their illness. Depression worsens MS. Thus, patients who are depressed with MS have a worse course of illness, and treatment of their depression improves the neurologic outcome of their illness.

Dr. Adam Kaplin graduated from Yale University before receiving his MD and Ph.D. from the Johns Hopkins University School of Medicine. Dr. Kaplin currently has a joint appointment as a Clinician-Researcher in the Departments of Psychiatry and Neurology at Johns Hopkins where he focuses his research on immune-mediated mechanisms of depression and cognitive impairment in CNS autoimmune diseases. He is the principle psychiatric consultant to the Johns Hopkins Multiple sclerosis and Transverse Myelitis Centers.

Dr. Kaplin is the inventor and co-developer of, an eHealth mood tracking technology that also functions as an electronic patient diary and a means to help individuals to coordinate care among their health care providers.

Dr. Kaplin is the Chairman of the Scientific Advisory Board for the Montel Williams MS Foundation, and a Medical Advisor to the Cody Unser First Step Foundation (CUFSF), the Transverse Myelitis Association (TMA), the Johns Hopkins Project RESTORE, and the Nancy Davis MS Foundation.  Learn about Dr. Kaplin

Additional Information:

Johns Hopkins Multiple Sclerosis Center

What is MS? - Hopkins Health Library

Johns Hopkins Mood Disorder Center
They provide a range of specialized clinical services at The Johns Hopkins Hospital and the Johns Hopkins Bayview Medical Center to patients with mood disorders, including depression and bipolar disorder.

What is Depression? - NIMH Publications

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