A selection of publications from the NeuroTranslational Drug Discovery Program's faculty and staff.
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Netupitant inhibition of substance-P mediated responses in NG108-15 cells is enhanced by palonosetron. Stathis M. et al. European Journal of Pharmacology. submitted
Pharmacological mechanisms of 5-HT3 receptor antagonists to prevent chemotherapy induced nausea and vomiting. Rojas C, and Slusher BS. European Journal of Pharmacology. accepted
Handbook for Proteolytic Enzymes. Glutamate Carboxypeptidase II. Slusher BS, Rojas C, Coyle JT. in press
Structure-Activity Relationships of Glutamate Carboxypeptidase II (GCPII) Inhibitors. Ferraris DV, Shukla K, Tsukamoto T. Curr Med Chem. 2012 Feb 3. [Epub ahead of print]
The Role of Glutamate Signaling in Pain Processes and its Regulation by GCP II Inhibition. Wozniak KM, Rojas C, Wu Y, Slusher BS. Curr Med Chem. 2012 Feb 2. [Epub ahead of print]
Glutamate in CNS Neurodegeneration and Cognition and its Regulation by GCPII Inhibition. Rahn KA, Slusher BS, Kaplin AI. Curr Med Chem. 2012 Feb 1. [Epub ahead of print]
Tissue Distribution of Glutamate Carboxypeptidase II (GCPII) with a Focus on the Central and Peripheral Nervous System. Marmiroli P, Slusher BS, Cavaletti G. [Epub ahead of print]
Glutamate Carboxypeptidase II in Diagnosis and Treatment of Neurologic Disorders and Prostate Cancer. C. Barinka, C. Rojas, B. Slusher, M. Pomper. Curr Med Chem. 2012 Feb 1;19(6):856-70.
Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Le A, Lane AN, Hamaker M, Bose S, Gouw A, Barbi J, Tsukamoto T, Rojas CJ, Slusher BS, Zhang H, Zimmerman LJ, Liebler DC, Slebos RJ, Lorkiewicz PK, Higashi RM, Fan TW, Dang CV. Cell Metabolism, 2012; 15(1): 110-21.
Orally active glutamate carboxypeptidase II inhibitor 2-MPPA attenuates dizocilpine-induced prepulse inhibition deficits in mice. Takatsu Y, Fujita Y, Tsukamoto T, Slusher BS, Hashimoto K. Brain Res, 2011; 1371:82-6.
Poly(ADP-ribose)polymerase inhibition counteracts renal hypertrophy and multiple manifestations of peripheral neuropathy in diabetic Akita mice. Drel VR, Pacher P, Stavniichuk R, Xu W, Zhang J, Kuchmerovska TM, Slusher BS, Obrosova IG. International Journal of Molecular Medicine, 2011; 28(4):629-35.
Development of a high-throughput method for the determination of pharmacological levels of plasma d-serine. Alt J, Rojas C, Wozniak K, Wu Y, Ferraris D, Tsukamoto T, Slusher B. Analytical Biochemistry, 2011;419(2):106-9.
Inhibition of xc- transporter-mediated cystine uptake by sulfasalazine analogs. Shukla K, Thomas AG, Ferraris DV, Hin N, Sattler R, Alt J, Rojas C, Slusher BS, Tsukamoto T. Bioorganic & Medicinal Chemistry Letters, 2011;21(20):6184-7.
Reduced BACE1 activity enhances clearance of myelin debris and regeneration of axons in the injured peripheral nervous system. Farah MH, Pan BH, Hoffman PN, Ferraris D, Tsukamoto T, Nguyen T, Wong PC, Price DL, Slusher BS, Griffin JW. J Neurosci. 2011 Apr 13;31(15):5744-54.
Glutamate carboxypeptidase activity in human skin biopsies as a pharmacodynamic marker for clinical studies. Rojas C, Stathis M, Polydefkis M, Rudek MA, Zhao M, Ebenezer GJ, Slusher BS.J Transl Med. 2011 Mar 9;9:27.
Recent advances in the discovery of D-amino acid oxidase inhibitors and their therapeutic utility in schizophrenia. Ferraris DV, Tsukamoto T. Curr Pharm Des. 2011;17(2):103-11.
Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1. Seltzer MJ, Bennett BD, Joshi AD, Gao P, Thomas AG, Ferraris DV, Tsukamoto T, Rojas CJ, Slusher BS, Rabinowitz JD, Dang CV, Riggins GJ. Cancer Res. 2010 Nov 15;70(22):8981-7. Epub 2010 Nov 2.
Bioanalysis of N-acetyl-aspartyl-glutamate as a marker of glutamate carboxypeptidase II inhibition. Thomas AG, Rojas CJ, Hill JR, Shaw M, Slusher BS. Anal Biochem. 2010 Sep 1;404(1):94-6. Epub 2010 Apr 29.
