cores: The Behavioral Core at the School of Medicine
The Behavioral Core at the School of Medicine

Mikhail Pletnikov, M.D., Ph.D. (Director), Michelle Potter, Ph.D. (Research Manager), and Joshua Crawford (Coordinator) provide expert help in behavioral phenotyping of genetically-engineered or manipulated mice and rats. The Core provides help in designing and running behavioral tests and analyzing the data. We help investigators evaluate different domains of rodent behavioral repertoires to address the diverse phenotyping needs of the Hopkins community.
 

Investigators
Mikhail V. Pletnikov, M.D., Ph.D.
Mikhail V. Pletnikov, M.D., Ph.D. is an Associate Professor in Department of Psychiatry at Johns Hopkins University School of Medicine. He received his M.D. in 1986 from I.M. Sechenov Moscow Medical Academy, Moscow, Russia and his Ph.D. in Normal Physiology in 1990 from P.K. Anokhin Institute of Normal Physiology, Moscow, Russia. He did his post-doctoral training under Dr Timothy H. Moran (1996-1999) at the Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine and under Dr Kathryn M. Carbone (1996-1999) at the laboratory of pediatric and respiratory viral infections, the Center for Biologics Evaluation and Research (CBER), the U.S. Food and Drug Administration. He joined faculty in Department of Psychiatry at Johns Hopkins University in 1999. His current research interests focus on understanding pathogenesis of human psychiatric disease with neurodevelopmental origin, e.g., schizophrenia and autism with particular emphasis on a role of gene-environment interactions and the neuro-immune interplay in the complex pathogenesis of psychiatric conditions. Dr Pletnikov is also Director of the Behavioral Core at the School of Medicine.  

Dr. Pletnikov can be reached by email at mpletnik@jhmi.edu.  Dr. Potter can be reached by email at mpotte10@jhmi.edu or by phone 443-287-6884 or cell 410-382-2656.  Joshua Crawford can be reached by email at brbbehavioralcore@gmail.com or by phone 443-287-4054 or cell 972-489-6381.
 
The following services are currently available at the Behavioral Core Facility
 In mice:
• PPI/startle response
• Morris water maze
• Forced swim test
• Fear conditioning
• Ultrasonic Vocalization Detection
• Elevated Plus maze
• Radial Arm Maze
• Passive-avoidance
• Active-avoidance
• Y-maze
• T-maze
• Rotarod
• Accelerating rotarod
• Heat sensitization
• Open field chamber
• Social Interaction
• Tail suspension test
• Radial Arm maze (2010)
• Potentiated Startle Response (shock based) (2010)

In rats:
• BBB (open field locomotor)
• Gridwalk/horizontal ladder
• Footprint
• Beam walk
• Trunk and/or Hindpaw mechanical allodynia
• Hindpaw thermal allodynia
• Gait analysis
• Fear conditioning
• PPI/Startle response
• Rotarod
• CatWalk (2010)