The Brain Science Institute currently offers six cores that provide research, development and sevices for the brain science community.
The Behavioral Core at the School of Medicine
Mikhail Pletnikov, M.D., Ph.D. (Director), Michelle Potter, Ph.D. (Research Manager), and Joshua Crawford (Coordinator) provide expert help in behavioral phenotyping of genetically-engineered or manipulated mice and rats. The Core provides help in designing and running behavioral tests and analyzing the data. We help investigators evaluate different domains of rodent behavioral repertoires to address the diverse phenotyping needs of the Hopkins community.
The High Throughput Screening Center for Neurogenetics
Min Li, M.D., with the assistance of Seth Blackshaw, Ph.D., oversees an institutional core facility that uses robotic equipment and personnel to perform high throughput screens with small molecules such as drugs and chemicals. This facility will extend these capabilities to testing genes (cDNA’s) and gene blockers (shRNA’s) in the same high throughput fashion. These capabilities will allow Johns Hopkins University neuroscience investigators to conduct tests in a dish, allowing them to rapidly identify the roles of specific genes in brain cells.
The Mouse Forward Genetics Center
Alex Kolodkin and David Ginty have embarked on an approach to understanding the role of genes in brain development that has the potential to be transformational.
The Neuro-Epigenetics Program
Epigenetics, the study of heredity not coded in DNA sequences, is at the center of modern medicine because it can help to explain the relationship between an individual’s genetic background, the environment, aging, and disease.
The Behavioral Testing Program at Homewood
Genetic modifications can only be evaluated to the extent that the behaviors in mice can be interpreted as the effects of specific brain processes.
Center for Brain Imaging Science
The Center for Brain Imaging Science (CBIS) is one of the important resources in the growth of the Brain Science Institute at Johns Hopkins University.