cores: The Mouse Forward Genetics Center
The Mouse Forward Genetics Center

Alex Kolodkin and David Ginty have embarked on an approach to understanding the role of genes in brain development that has the potential to be transformational. The study of genetic mutations has driven many major discoveries in neuroscience, but the capacity to assess the effect of mutations in an unbiased way – across the entire genome – has largely been restricted to studies in worms and other invertebrates. Studies in mice have largely used chemicals to induce random mutations in the genetic code. Drs. Ginty and Kolodkin will use innovative techniques to insert tagged gene modifiers, so that large numbers of “tagged” mutations will be present in each mouse pup, greatly facilitating the assessment of the consequences of these mutations in nervous system development and function. This high-risk technique has the potential to identify many new genes that control specific aspects of brain development, function, and disease. The mouse lines developed in this Center will be available to all Johns Hopkins neuroscientists.

Investigators
David Ginty, Ph.D.
David Ginty, Ph.D., is a Professor of Neuroscience and an Investigator of the Howard Hughes Medical Institute. He received a bachelor degree in Biology from Mount Saint Mary’s College and a Ph.D. degree in Physiology from East Carolina University School of Medicine. He is the recipient of several faculty awards, including an NINDS Jacob Javits Neuroscience Investigator Award, a Pew Scholars Award, and an American Cancer Society Faculty Research Award.  Dr. Ginty can be reached by email at dginty@jhmi.edu or by phone 410-614-9494.
 
Alex Kolodkin, Ph.D.
Alex Kolodkin, Ph.D., is a Professor of Neuroscience and an Investigator of the Howard Hughes Medical Institute. He received a B.A. in Biology from Wesleyan University and a Ph.D. in Molecular Biology from the Institute of Molecular Biology at the University of Oregon. He has received several awards, including the McKnight Neuroscience Investigator Award, the Javits Neuroscience Investigator Award from the National Institute of Neurological Disorders and Stroke, and the Searle Scholars Award.  Dr. Kolodkin can be reached by email at kolodkin@jhmi.edu or by phone 410-614-9499.

Mouse Forward Genetics Center Service Application

 
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